Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents

Table 3 Transcripts regulated by 2 μg Se/g diet

Genbank Accession	Gene Symbol	Gene Title	Fold Change¹	adj P-value²	Nrf2 Target³
NM_017214	Rgs4	regulator of G-protein signaling 4	3.03	0.005	X
NM_022543	Ccdc80	coiled-coil domain containing 80	2.14	0.02
XM_001069576	RGD1560666	Similar to KIAA1280 protein	1.80	0.02
NM_001127580	Oxct1	3-oxoacid CoA transferase 1	1.64	0.02
NM_031147	Cirbp	cold inducible RNA binding protein	-1.83	0.02
BE107169	EST	UI-R-BS1-ayq-f-06-0-UI.s1	1.70	0.03
			- - - - - - - - - - - - - - - - - - - - - - - - -
NM_001009965	Tsku	Tsukushin	2.30	0.13	X
NM_001011901	Hsph1	heat shock 105 kDa/110 kDa protein 1	1.68	0.13
NM_012886	Timp3	TIMP metallopeptidase inhibitor 3	1.68	0.13
AA945268	EST	EST200767	-3.25	0.19
NM_001164396	RGD1564865	similar to 20-alpha-hydroxysteroid dehydrogenase	-2.14	0.13

Transcripts that were significantly (above the dashed line, P < 0.05) or nearly significantly (below the dashed line, 0.05 < P < 0.2) differentially expressed in liver from rats fed 2 μg Se/g diet compared to 0.24 μg Se/g diet. ¹Fold changes determined by analysis of RMA expression data with the Limma package in R software, ²P-values were adjusted for multiple testing, ³Genes known to be Nrf2 targets, determined as described in the text.

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