Table 3 Unique genes with increased expression in spleen after SGIV infection
Gene name | species | expression in normal | Expression in infection | Fisher p_value |
|---|---|---|---|---|
Profilin-2 | Rattus norvegicus | 305 | 29051 | 0 |
60S ribosomal protein | Homo sapiens | 251 | 23569 | 0 |
Eotaxin | Mus musculus | 3169 | 17689 | 0 |
Granulins | Rattus norvegicus | 1141 | 15720 | 0 |
Leukocyte cell-derived chemotaxin-2 | Mus musculus | 4809 | 10637 | 0 |
Thioredoxin | Ictalurus punctatus | 542 | 7343 | 0 |
Saposin-C | Cavia porcellus | 43 | 5116 | 0 |
Cystatin-B 1 | Macaca fuscata | 92 | 4388 | 0 |
Perforin-1 | Mus musculus | 105 | 4097 | 0 |
Scavenger receptor cysteine-rich type 1 protein | Canis familiaris | 911 | 3958 | 0 |
Eukaryotic translation initiation factor 4 gamma 2 | Gallus gallus | 573 | 3829 | 0 |
Gamma-glutamyl hydrolase | Homo sapiens | 133 | 2638 | 0 |
Legumain | Bos taurus | 445 | 2572 | 0 |
Proteasome subunit alpha type-7 | Carassius auratus | 35 | 2452 | 0 |
Glyceraldehyde 3-phosphate dehydrogenase, | Danio rerio | 103 | 1983 | 0 |
Transcription factor BTF3 | Mus musculus | 83 | 1770 | 0 |
Src-like-adapter | Mus musculus | 84 | 1371 | 2.02E-303 |
Keratin 8 | Gallus gallus | 182 | 1586 | 5.86E-283 |
Galectin-3-binding protein B | Danio rerio | 450 | 2187 | 8.23E-277 |
SUMO-conjugating enzyme | Xenopus tropicalis | 137 | 1307 | 8.94E-243 |
C-C motif chemokine 18 | Macaca mulatta | 282 | 1667 | 3.00E-242 |
Galectin-3-binding protein A | Danio rerio | 371 | 1747 | 3.37E-216 |
Hemoglobin subunit beta-1 | Pseudaphritis urvillii | 241 | 1383 | 1.38E-197 |
Keratin 18 | Oncorhynchus mykiss | 1661 | 3701 | 7.37E-180 |
Eukaryotic translation initiation factor 3 | Bos taurus | 67 | 844 | 4.27E-174 |
Cytochrome b | Tropheus moorii | 6544 | 9945 | 1.29E-163 |
Natural killer cell protease 1 | Rattus norvegicus | 227 | 1138 | 1.95E-148 |
T-complex protein 1 | Gallus gallus | 50 | 669 | 6.61E-141 |
RNA-binding protein 5 | Xenopus tropicalis | 45 | 605 | 7.97E-128 |
Cathepsin H | Sus scrofa | 391 | 1347 | 3.79E-125 |
Beta-2-glycoprotein 1 | Bos taurus | 433 | 1389 | 7.97E-119 |
Dipeptidyl peptidase 1 | Bos taurus | 55 | 586 | 1.36E-114 |
Proto-oncogene vav | Mus musculus | 98 | 693 | 8.51E-113 |
Proteasome subunit alpha type-4 | Homo sapiens | 684 | 1761 | 2.56E-111 |
Actin-related protein 2/3 complex subunit 5 | Mus musculus | 90 | 656 | 1.35E-108 |
Proteasome subunit beta type-6-B like | Salmo salar | 469 | 1361 | 8.49E-103 |
RING-box protein 2 | Mus musculus | 42 | 497 | 3.76E-101 |
NADH-ubiquinone oxidoreductase chain 1 | Carassius auratus | 330 | 1102 | 2.68E-99 |
Phospholipid hydroperoxide glutathione peroxidase | Sus scrofa | 590 | 1527 | 1.66E-97 |
Retinol-binding protein 1 | Bos taurus | 164 | 767 | 1.80E-95 |
NudC domain-containing protein 2 | Rattus norvegicus | 81 | 576 | 3.36E-94 |
Lysozyme g | Epinephelus coioides | 164 | 742 | 5.02E-90 |
Voltage-gated hydrogen channel 1 | Danio rerio | 217 | 742 | 4.09E-69 |
Ubiquitin-like modifier-activating enzyme 5 | Xenopus laevis | 179 | 670 | 8.17E-69 |
LRR and PYD domains-containing protein 1 | Homo sapiens | 205 | 714 | 6.02E-68 |
Cytochrome c oxidase subunit 6B1 | Tarsius syrichta | 60 | 395 | 2.33E-62 |
Ig lambda chain | Homo sapiens | 31 | 315 | 2.99E-61 |
Interleukin-8 | Equus caballus | 155 | 572 | 4.14E-58 |
Fibroleukin | Homo sapiens | 611 | 1281 | 3.75E-56 |
Rho GDP-dissociation inhibitor 1 | Macaca fascicularis | 325 | 844 | 4.69E-55 |
Ependymin | Notemigonus crysoleucas | 70 | 386 | 5.52E-55 |
Fucolectin-4 | Anguilla japonica | 1519 | 2434 | 1.29E-50 |
Complement factor H | Homo sapiens | 131 | 459 | 1.88E-44 |
Eukaryotic initiation factor 4A-III | Xenopus tropicalis | 56 | 282 | 4.32E-38 |
Cysteine and glycine-rich protein 2 | Mus musculus | 61 | 290 | 1.68E-37 |
Proliferating cell nuclear antigen | Haplochromis burtoni | 237 | 575 | 3.64E-34 |
Secernin-3 | Danio rerio | 64 | 277 | 2.42E-33 |
Ubiquitin-conjugating enzyme E2 | Mus musculus | 74 | 286 | 4.09E-31 |
Heat shock cognate 71 kDa protein | Oryzias latipes | 25 | 181 | 8.31E-31 |