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Figure 3 | BMC Genomics

Figure 3

From: Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages

Figure 3

Epigenetic responses to individual lipoproteins. A, dose-response for global DNA methylation. Solid squares, VLDL; open squares, LDL; solid circles, HDL. 5 mdC, 5-methyldeoxycytosine. For simplicity, significance levels are shown only for highest dose-responses compared to respective controls. B, time-course of global DNA methylation response following stimulation with individual lipoprotein at 91.1 μg protein/ml concentration. Symbols as in A. C and D, effects on histone posttranslational modifications. Significance levels are for comparisons with the respective control. One, two and three stars indicate P < 0.05, P < 0.01 and P < 0.005 significance level, respectively (Scheffé test). Bars, standard deviations.

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BMC Genomics

ISSN: 1471-2164

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