The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3′ UTR

Table 1 Transcription factors association with gene data set

Rank	Matrix	Transcription factor	Association score	p-value
1	NFKAPPAB65_01	Rela	15.083	0.00
2	NFKB_Q6_01	Nf-κb1, Nf-κb2	13.488	0.00
3	NFKAPPAB_01	Rela	13.336	0.00
4	CREL_01	C-rel	12.883	0.00
5	NFKB_Q6	N/A	11.200	0.00
6	NFKB_C	N/A	9.671	0.00
7	NFKAPPAB50_01	N/A	7.199	0.00
8	CDPCR1_01	Cutl1	5.367	8.30 × 10^-5
9	CDPCR3HD_01	Cutl1	5.265	1.03 × 10^-4
10	PAX2_01	Pax-2 , Pax-2a	4.845	2.66 × 10^-4

PASTAA results for TFs associated with input set of genes ranked by p-values. Values were obtained for human sequences and human-mouse conserved sequence blocks. PASTAA settings: promoter sequence length closest to that considered in our study was 400 bp upstream TSS, affinity level: maximum affinity across promoter range.

ISSN: 1471-2164