Figure 1
From: Genome-wide association between DNA methylation and alternative splicing in an invertebrate
The distribution of DNA methylation among included exons vs. skipped exons. The plots in (A) and (B) illustrate that exons that are included in transcription are higher methylated than exons that are skipped during transcription. The absolute methylation (mCG/length) around exons was calculated by dividing the regions +/− 200 bp within the start site (A) or end site (B) of either included exons or skipped exons into 20 equal intervals. Plots show the methylation level within each interval. Included exons have significantly more methylation than skipped exons in regions beginning after the exon start site and just before the exon end site (P < .05, Wilcoxon rank-sum test in each interval). Genome-wide DNA methylation data were obtained from BS-seq[18].