Figure 8

Detection of potential sequence errors. Examples of sequence discrepancies (highlighted in blue) that are identified in the subfamily alignments. A) Potential mispredicted exons, resulting in suspicious sequence segments, are identified based on the conserved blocks in the subfamily alignment. B) Potential start and stop site errors are predicted based on the distribution of the positions of the N/C-terminal residues. C) Identification of a potential inserted intron, based on the presence of a single sequence with the insertion in a given subfamily. D) Identification of a potential missing exon, based on the presence of a single sequence with a deletion in a given subfamily.