Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

BMC Genomics

Table 3 Enrichment analysis of high confidence LXR target genes

Term	Count	%	P	FE	FDR
translation	16	6.56	9.14E-05	3.34	0.15
lipid biosynthetic process	15	6.15	2.48E-04	3.21	0.41
cellular response to stress	20	8.20	5.40E-04	2.44	0.89
RNA splicing	13	5.33	8.58E-04	3.16	1.41
response to virus	8	3.28	1.00E-03	5.07	1.64
positive regulation of gene-specific transcription	7	2.87	1.59E-03	5.55	2.60
RNA splicing, via trans-esterification reactions	9	3.69	1.68E-03	4.06	2.75
nuclear mRNA splicing, via spliceosome	9	3.69	1.68E-03	4.06	2.75
RNA splicing, via trans-esterification reactions with bulged adenosine as nucleophile	9	3.69	1.68E-03	4.06	2.75
RNA processing	18	7.38	2.41E-03	2.27	3.90
negative regulation of cholesterol storage	3	1.23	2.98E-03	34.51	4.82

The analysis was performed using the DAVID tool [37] for the specific set of LXR target genes with P < 0.001 for differential expression. GO biological process terms with FDR < 5% are shown. Columns indicate the GO-term, its count and percentage in the target gene list, as well as the P-value, FE and FDR for the enrichment.

ISSN: 1471-2164