Table 2 Results of the Gene Ontology (GO) analysis including closest genes to SNP with P<5.0E-05
Go sub-ontology | GO term accession | GO term description | Number of involved genes | Involved genes | DAVID P-value |
|---|---|---|---|---|---|
Biological Process | GO:0050767 | regulation of neurogenesis | 5 | ACTR3, LINGO1, IRX3, XRCC2, DLL1 | 0.015 |
Biological Process | GO:0006928 | cell motion | 8 | ACTR3, CXCR4, SPOCK1, SCNN1G, IL12B, APBB2, ELMO1, CTNNA2 | 0.018 |
Biological Process | GO:0051960 | regulation of nervous system development | 5 | ACTR3, LINGO1, IRX3, XRCC2, DLL1 | 0.024 |
Biological Process | GO:0060284 | regulation of cell development | 5 | ACTR3, LINGO1, IRX3, XRCC2, DLL1 | 0.029 |
Biological Process | GO:0030182 | neuron differentiation | 7 | LINGO1, CXCR4, MTPN, APBB2, OLFM3, NTM, CTNNA2 | 0.038 |
Biological Process | GO:0045664 | regulation of neuron differentiation | 4 | ACTR3, LINGO1, IRX3, DLL1 | 0.040 |
Biological Process | GO:0048666 | neuron development | 6 | LINGO1, CXCR4, APBB2, OLFM3, NTM, CTNNA2 | 0.044 |
Molecular Function | GO:0031420 | alkali metal ion binding | 5 | KCNK9, KCNT2, ATP1B3, SLC22A4, SCNN1G | 0.031 |
Molecular Function | GO:0000166 | nucleotide binding | 19 | RBM24, XRCC2, SUCLG2, PKN2, ABCB1, ACTR3, MAP3K5, KCNT2, HIPK1, ASCC3, PDE1C, CELF4, SLC22A4, CELF2, DPYD, RAB38, DOCK10, ARL4C, MOCS1 | 0.038 |
Cellular Component | GO:0043005 | neuron projection | 7 | NUMA1, CXCR4, MTPN, PARK2, APBB2, DTNBP1, CTNNA2 | 0.009 |
Cellular Component | GO:0031252 | cell leading edge | 4 | ACTR3, CXCR4, APBB2, CTNNA2 | 0.037 |