Figure 10

Hypoxia affects transcript levels of enzymes involved in the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, glutamate biosynthesis and the GABA shunt. A. KEGG heat map representation of genes involved oxidative phosphorylation comparing transcript levels at the indicated times after exposure to hypoxic conditions to time point immediately prior to hypoxia exposure (0 hours). Yellow indicates transcript level is higher. Scale on left indicates intensity of expression. B. KEGG heat map representation of genes involved in the TCA cycle, comparing transcript levels at the indicated times after exposure to hypoxic conditions to time point immediately prior to hypoxia exposure (0 hours). Yellow indicates transcript level is higher. Scale on left indicates intensity of expression. C. Heat map representation of transcripts involved in glutamate biosynthesis, including transcripts associated with the GABA shunt. Both heat maps compare wild type Aspergillus fumigatus strain CBS144.89 at the indicated times after exposure to hypoxic conditions to time point immediately prior to hypoxia exposure (0 hours). Yellow indicates transcript level is higher, and values are sorted by the 24-hour time point.