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Table 2 Distribution of results over CpG islands and shores

From: Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects

Location Illumina Human Methylation 27 Methylation & expression cis Methylation & expression trans Methylation & expression & SNP cis
Island 11,582 42% 70 13.5%, p <2.2e-16↓ 269 38.2%, p=0.04 11 15.1%, p =1.1e-06↓
Island shore (2kb) 8,718 32% 184 35.6%, p=0.056 172 24.4%, p =3.9e-05↓ 39 53.4%, p =1.3e-04↑
Outside island/shore 7,278 26% 263 50.9%, p <2.2e-16↑ 264 37.4%, p =2.5e-10↑ 23 31.5%, ns
Total 27,578   517   705   73  
  1. Methylation probes were classified into three categories according to UCSC browser (http://genome.ucsc.edu/); CpG islands, CGI shores (up to 2kb around an island) and outside islands or shores. Differences compared to Illumina Human Methylation 27K array were tested using Fisher’s Exact for count data (Bonferroni threshold p:0.05/9=0.006). A downward arrow indicates significantly lower percentage of probes while an upward arrow indicates significantly higher percentage of observations compared to the overall probe distribution on the Illumina array.