Figure 3

Core and pan-genome model of 67 S. mutans genomes. a) Core-genome model of S. mutans. The core-genome size (number of common genes) is plotted as a function of the number (n) of genomes according to a previously proposed model $F_c\left(n\right)={\kappa }_{c}exp⌊\raisebox{1ex}{$-n$}\!\left/ \!\raisebox{-1ex}{${\tau }_c$}\right.⌋+\mathrm{\Omega },$ where K _c , τ_c and Ω are model parameters. Red rectangles are the medians of the core-genome sizes calculated by random sampling 1000 different genome combinations of n genomes out of 67 genomes. Blue bars are the standard deviation of the medians. The red bars are weights used for model fitting and the red curve is the fitting result. b) Pan genome modeling of S. mutans genomes using three models, y = a + bx^c, y = a − bln(x + c) and y = a × e^{− x/b} + c (where a, b and c are parameters), represented by green, blue and red curves respectively. Black rectangles are the medians of the pan-genome sizes calculated by random sampling 1000 different genomes combination of n genomes out of 67 genomes, and black bars are the standard deviations of the medians.