Figure 6

Central metabolism pathways of mutans streptococci. The orange lines represent enzyme reactions conserved across the mutans streptococci strains compared in this study, whereas the blue lines represent enzyme reactions specifically present (solid line) or absent (dashed line) in S. sobrinus DSM 20742. Reaction catalyzed by NAD⁺-specific malic enzyme (EC: 1.1.1.38) (green line) is absent in S. mutans NN2025 and S. mutans AC4446. Pyruvate-phosphate dikinase, catalyzing the interconversion of PEP and pyruvate (black line), is uniquely present in S. ratti DSM 20564.