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Table 3 The natural variation in CD epitopes in T. turgidum

From: Quantitative and qualitative differences in celiac disease epitopes among durum wheat varieties identified through deep RNA-amplicon sequencing

CD epitope name

Natural sequence variation

DQ2.5-glia-α1a

PFPQPQLPY

DQ2.5-glia-α1b

PYPQPQLPY

α1a-variant 1

PFLQPQLPY

α1a-variant 2

PFPQPQLSY

α1a-variant 3

PFSQPQLPY

α1a-variant 4

PFPPPQLPY*

α1a-variant 5

PFPQLQLPY*

DQ2.5-glia-α2

PQPQLPYPQ

α2-variant 1

PQPQLPYSQ

α2-variant 2

SQPQLPYSQ

α2-variant 3

PQPQLSYSQ

α2-variant 4

PPPQLPYSQ*

α2-variant 5

LQPQLPYSQ

α2-variant 6

FPPQLPYPQ

α2-variant 7

FLPQLPYPQ

DQ2.5-glia-α3

FRPQQPYPQ

α3-variant 1

FPPQQPYPQ

α3-variant 2

FSPQQPYPQ*

α3-variant 3

FLPQQPYPQ

α3-variant 4

FPSQQPYPQ

α3-variant 5

FPPQQSYPQ

α3-variant 6

FQPQQPYPQ

α3-variant 7

FRPQQSYPQ

  1. The natural sequence variation in HLA-DQ2.5 restricted T cell epitopes involved in CD (in their natural, non deamidated form); DQ2.5-glia-α1a and DQ2.5-glia-α1b, DQ2.5-glia-α2, DQ2.5-glia-α3, as present in cDNAs of T. turgidum accessions. Canonical CD epitope sequences in bold. * variants that have not previously been found in T. aestivum[11].
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BMC Genomics

ISSN: 1471-2164

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