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Figure 4 | BMC Genomics

Figure 4

From: Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin

Figure 4

Morphemes in DNA fragments that interact with MLL1 in DNA binding and functional assays. (A) Sequences analyzed in DNA binding or transient expression assays. Probe 1 corresponded to insert 1, shown in Figure 2A; probe 2 was derived from the HSV TK promoter [53]. Colored sequences highlight the position of MLL1 morphemes in probe 1 and probe 2 (B) MLL1 morphemes in a DNA segment from the mouse Hoxa9 gene. This segment includes the promoter of a Hoxa9 transcript [54]. Colored sequences highlight CpG-rich clusters that in vivo MLL1 protected from methylation [54]. Color-coding follows the scheme in Figure 2B.

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BMC Genomics

ISSN: 1471-2164

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