Table 7 Differentially expressed genes after infection with high bulk frequency ratios and low combined allele ratio
Gene | BFR | Combined allele ratio | Known function |
|---|---|---|---|
Metalloreductase STEAP2 | 21.2 | 3 | Regulates iron ion homeostasis and involved in endocytosis |
Tumor suppressor candidate 5 homolog | 34.0 | 2.3 | Inhibits breast tumor formation in vivo |
Protein G7c-like | 17.8 | 3.2 | Effect the susceptibility to lung tumors |
Acidic chitinase-like | 9.8 | 1.4 | Participates in the defense against nematodes, fungi and bacteria. Plays a role in T-helper cell type 2 (Th2) immune response. |
Mannan-binding lectin serine peptidase 2 | 4.1 | 2.2 | Lectin complement pathway actication |
Inter-alpha-trypsin inhibitor heavy chain H4 | 4.3 | 1.3 | Type II acute-phase protein (APP) involves in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
D-amino acid oxidase | 4.3 | 1.8 | Regulation of the glutamatergic neurotransmission; may play a role in the glutamatergic mechanisms of schizophrenia |
MAWD binding protein like | 4.4 | 1.4 | Inhibits proliferation and invasion in gastric cancer |
Cytokeratin-like | 4.5 | 1.5 | Mediate epithelial innate defense through their antimicrobial properties |
Spermidine/spermine N1-acetyltransferase | 4.7 | 1 | Involves in polyamine homeostasis |
Stonustoxin subunit alpha-like | 4.7 | 1.9 | Induces hemolytic activities, displays edema-inducing activities, increases vascular permeability and interferes irreversibly with neuromuscular function. |
UDP-glucose 4-epimerase | 4.8 | 1.8 | Catalyzes the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. |
Major histocompatibility complex class I UDA | 5.1 | 3.1 | Play an important role in immune response and antigen processing and presentation |
NLR-C8 | 5.9 | 1.4 | Involves in the gram negative bacteria recognition. Against the intracellular pathogen. |
MARCKS-like 1a | 6.1 | 2.5 | Most prominent cellular substrate for protein kinase C. It can bind calmodulin, actin, and synapsin. |
3-oxoacid CoA transferase 1a | 7.0 | 1.3 | Key enzyme for ketone body catabolism. Also plays and important roles in the energy metabolism of spermatozoa. |
MHC class II beta chain | 17.9 | 2.4 | Involves in antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |