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Table 1 The top 10 terms of GO functional ontologies.

From: Post genome-wide association studies functional characterization of prostate cancer risk loci

GO terms

Observed*

p-value#

GO Biological Processes

  

Regulation of cell death

40

4.944 × 10-9

Regulation of apoptosis

39

5.506 × 10-9

Regulation of programmed cell death

39

6.945 × 10-9

Response to external stimulus

39

1.237 × 10-8

Metabolic process

133

2.357 × 10-8

Epithelial cell proliferation

9

7.699 × 10-8

Response to organic cyclic compound

19

1.153 × 10-7

Negative regulation of biological process

61

1.650 × 10-7

Rhythmic process

15

2.056 × 10-7

Branching morphogenesis of a tube

12

2.070 × 10-7

GO Molecular Functions

  

Insulin-like growth factor receptor binding

11

6.617 × 10-18

Insulin receptor binding

10

1.501 × 10-12

Protease binding

11

1.685 × 10-11

Binding

156

1.574 × 10-10

Protein binding

115

1.593 × 10-9

Protein complex binding

17

2.310 × 10-7

Hormone activity

10

4.671 × 10-6

Catalytic activity

76

3.102 × 10-5

Oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

5

6.596 × 10-5

4 iron, 4 sulfur cluster binding

4

8.215 × 10-5

GO Localizations

  

Cytoplasmic part

99

1.009 × 10-6

Mitochondrial envelope

19

2.992 × 10-6

Mitochondrial part

22

9.733 × 10-6

Envelope

23

1.480 × 10-5

Mitochondrion

34

2.505 × 10-5

Organelle envelope

22

3.432 × 10-5

Mitochondrial inner membrane

13

7.758 × 10-5

Mitochondrial respiratory chain complex I

5

7.937 × 10-5

NADH dehydrogenase complex

5

7.937 × 10-5

Respiratory chain complex I

5

7.937 × 10-5

  1. * Number of the observed genes of the gene list in the category
  2. # p-values were calculated by FDR (0.05) adjustment