Figure 4
From: Functional chromatin features are associated with structural mutations in cancer
Synergy between multiple proteins. A. Odds ratio for enrichment of protein bindings in the vicinity of SM breakpoints (within 50 kb) as a function of the number of bound proteins (in the Breast-Stephens callset). Protein binding data are from the ENCODE A549 cell line as measured in the HAIB lab. B. Comparison of sites with evidence of binding exactly 2 proteins vs. exactly 1 protein. The vertical axis shows log2 odds ratio (mean ± standard error), where mean and error are calculated based on the number of cell line × lab combinations with available data (n) for at least 2 proteins. Statistical significance (p) is with respect to a null model of log-odds ratio being 0 (horizontal dotted line).