Figure 4

Protein-protein interaction network for the high-MI group. Nodes are proteins extracted from the PhosphoPOINT database using the name of kinases in the low-MI group as input. Edges represent the relationship between proteins: black edge (1) for interacting proteins; blue edges (2) for interacting proteins as well as phosphoproteins; red edges (3) for substrates and purple edges (4) for substrates as well as interacting phosphoproteins. The insert shows the mitosis regulatory module" that includes the polo-kinase 1 PLK1, the mitotic checkpoint kinase BUB1, the membrane-associated kinase PKMYT1 and the cell cycle division kinase CDC7.