Figure 9
From: Transcriptomic changes during regeneration of the central nervous system in an echinoderm
Expression of pluripotency factors in regeneration of the radial organ complex in the sea cucumber H. glaberrima . Summary of the digital expression assay and homology search against the UniProt database. Red and blue colors indicate significant (adjusted p < 0.001, more than two fold change in expression level) up-regulation or down-regulation, respectively, in the regenerating tissues as opposed to uninjured organs. NS, no significant changes in expression was observed. *Note that the gene designated as Oct1 is included in this list because it is the only Oct homolog found in the H. glaberrima transcriptome. Likewise, Oct1/2 is the only Oct in the sea urchin genome [44]. In mammals, there are a number of other Oct genes that perform various essential roles. One of them, Oct4 was used to induce pluripotency in mammalian somatic cells [41, 45].