Figure 4

Amino acid sequences from L. hesperus transcripts containing predicted inhibitory cystine knot (ICK) motifs. Sequences with BLAST homology to known ICK toxin sequences (A) or lacking a BLAST hit but possessing a predicted ICK scaffold (B). The cysteine spacing is numbered by the sequence in the mature toxin. The predicted signal peptide is shaded gray, and the KNOTER1D predicted disulfide connectivity is indicated by colored bars and cysteine residues. Cysteines not predicted to participate in disulfide bonds are underlined. 1=venom_comp104578_c0_seq1, 2=venom_comp104578_c0_seq3, 3=venom_comp104578_c0_seq6, 4=Contig7465, 5=venom_comp72844_c0_seq1, 6=Contig3061, 7=Contig5795, 8=Contig7277, 9=venom_comp98528_c0_seq1, 10=venom_comp75139_c0_seq1, 11= Contig20358.