Figure 4

Scheme of affected cellular processes. The scheme of the adipocyte visualizes prominent cellular processes that are over-represented in the eight analyzed groups. The structures and name of the corresponding group have same colors. The TC:up/TL:up (“translation”) group is represented by ribosomes. The TC:up/TL:unchanged (“metal”) group is symbolized by zinc (channels). The TC:up/TL:down (“thrombospondin”) group is represented by thrombospondin binding to a receptor. Analogously, we chose receptor symbols for the TC:unchanged/TL:up (“olfactory”) group and the TC:down/TL:down (“Egfr and Ghrl”) group. The yellow arrow symbolizes signaling of the TC:down/TL:up (“signaling”) group, e.g. via phosphorylation cascades as initialized by receptor dimerization. The TC:unchanged/TL:down (“methylation and repair”) group is denoted by methyl groups attached to the DNA in the nucleus. The TC:down/TL:unchanged (“regulation”) group is represented by a traffic light.