Figure 1
From: Functional annotation signatures of disease susceptibility loci improve SNP association analysis
Two–staged procedure for integrating variant–level functional annotation data with subject–level genetic association data. At the first stage, functional annotation data are combined to estimate the prior (to observing the genetic association data) probability of association for each variant. At stage two, these estimates are combined with the Bayes Factor (a metric of association) in favor of genetic association via Bayes’ formula to estimate the posterior (to observing the functional and genetic association data) probability of association for each variant.