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Table 5 Differentially expressed Wnt signalling pathway genes

From: Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways

Down-regulated Wnt Pathway genes

Fold change

Gene symbol

Gene title

Role in pathway

Reference for role in pathway

RNA-seq

Microarray

Ligand

Receptor

Intra-cellular

Target

  #

41.05

Fgf4

Fibroblast growth factor 4

   

T

[37]

  #

 

Snai3

Snail homolog 3

   

PT

Snai1[38]

  90.87

32.06

Cacng1

Calcium channel, voltage-dependent, gamma subunit 1

   

T

[39]

  42.86

18.77

Pitx3

Paired-like homeodomain transcription factor 3

   

PT

Pitx2[40]

  37.43

17.22

Kremen2

Kringle containing transmembrane protein 2

 

Co-Rec

 

[41]

  29.52

 

Ccnb3

Cyclin B3

   

PT

CyclinD1[42]

  12.29

7.05

Rxrg

Retinoid X receptor gamma

   

PT

Rarg[43]

  5.95

5.20

Islr2

Immunoglobulin superfamily containing leucine-rich repeat 2

  

PT

Islr[44]

  4.87

 

Pitx2

Paired-like homeodomain transcription factor 2

   

T

[40]

  3.58

 

Fzd10

Frizzled homolog 10

 

R

  

[45]

  3.16

2.21

Dll1

Delta-like 1

   

T

[46]

  3.05

 

Prg4

Lubricin

   

T

[30]

  2.81

2.57

Lrrn1

Leucine rich repeat protein 1, neuronal

   

T

[47]

  2.52

 

Sall1

Sal-like 1

   

PT

Sall4:[36]

  2.47

 

Tnik

TRAF2 and NCK interacting kinase

  

TF-act

[48]

  2.32

 

Tcf15

Transcription factor 15

   

T

 

  2.32

 

Met

Met proto-oncogene

   

T

[49]

  2.18

2.28

Cd44

CD44 antigen

   

T

[50]

  2.09

 

Jag2

Jagged2

   

PT

Jag1[51]

Up-regulated Wnt pathway genes

  4.36

4.91

Grem2

Gremlin

   

T

[52]

  3.96

 

Wnt2

Wingless-related MMTV integration site 2

L

    

  3.50

 

Wnt2b

Wingless-related MMTV integration site 2b

L

    

  3.07

 

Wnt16

Wingless-related MMTV integration site 16

L

    

  2.85

2.90

Kcnd2

Potassium voltage-gated channel, shal-related family, member 2

 

T

[47]

  2.73

 

Cldn1

Claudin-1

   

T

[53]

  2.44

 

Dkk2

Dickkopf

Ant

 

T

[47, 54]

  2.43

3.08

Rspo2

R-spondin 2

L

  

T

[47, 55, 56]

  2.37

 

Epha4

Eph receptor A4

   

T

[47]

  2.11

 

Elavl2

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2

 

T

[47]

  2.10

 

Cpz

Carboxypeptidase Z

Co-act

  

[33]

  2.09

2.62

Sfrp2

Secreted frizzled related protein 2

Ant

 

T

[57]

  2.03

 

Wnt4

Wingless-related MMTV integration site 4

L

    

  2.02

 

Rspo3

R-spondin 3

L

  

T

[47, 58]

 

2.41

E330013P04Rik

RIKEN cDNA E330013P04 gene

   

T

[47]

  1. #No numerical value for fold change as no transcripts detected in the Mutant.
  2. T -Target, PT -Potential Target, R -Receptor, Co-Rec -Co-Receptor, TF-act -Transcription Factor activator, L -Ligand, Ant -Antagonist, Co-act -Co-activator.