Figure 3

Genomic context of CTLP events. (A) Example copy number profiles of chromosomes with changes suggestive of chromothripsis. In these examples, chromosomal fragmentation events are related to other types of copy number aberrations, and exhibit different combination patterns. The x-axis indicates genomic locations in Mb, and the y-axis is the log2 value of probe signal intensity. Yellow and blue lines represent called genomic gains and losses respectively. (B) Distribution of CNAs as fraction of the genome, compared between CTLP and non-CTLP cases. CT, chromothripsis-like. (C) Distribution of CNA fractions for individual samples. For the non-CTLP group, 918 samples were randomly chosen from the total set of 17,476 cases, to generate an equally sized comparison. The p-value, indicating significant difference between the genome fraction distributions of two groups, is based on a Kolmogorov-Smirnov test. The fractions for each sample have been calculated as sum of genome bases chromosomes 1–22 divided by the sum of all CNAs in the sample (with and without CTLP regions).