Figure 3
From: MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression
Histogram of qRT-PCR measurements of miR-34c regulated targets in TPCH-KCO dataset. Genes differentially expressed between transformed and scrambled sequence controls in respiratory cell lines were independently tested in TPCH-KCO dataset using qRT-PCR. This step minimizes false positives and ensures that authentic genes are discovered. Average gene expression in mild and moderate emphysema lungs are represented in the Y-axis and genes on the X-axis. SERPINE1 was significantly upregulated in emphysema lungs. HNF4 was also upregulated but did not attain significance.