Figure 3
Representation of the XRRA1 genomic structure. (A) The XRRA1 gene spans 64 kb and comprises 11 exons. HCT116Clone2_XRR cells contain 2 splice variants, one of which lacks exon 3 and is truncated. Other cDNA clones such as BC032794 lack exon 4, AK074152 lacks exon 3–4 and possible partial deletion of exon 5, and AK056364 lacks exon 2–4 and 10. The gene is located between genomic markers D11S916-D11S911 (80.1–84.2 cM) or at position 625.9 cR of NCBI RH Map. (B) The assembled Hs XRRA1 comprises a putative promoter region, start/stop codons and poly-A signal, and predicted a protein with motifs such as LRR, PEST, and NLS. Scale bar is multiplied by 100.