Figure 1

Phylogenetic tree of C. elegans and C. briggsae Ground and Ground-like domains. Multiple sequence alignment of Ground and Ground-like domains were generated using MAFFT [see Additional file 3]. For grd-1, grd-2 and grd-11 the four Ground domains were extracted manually prior to alignment; the R1 to R4 postscripts indicate which repeat it is. Neighbor joining was performed on the aligned sequences using the default parameters of Clustal_X. Results of 100 bootstrap trials are shown. In addition to the C. elegans and C. briggsae sequences, some Brugia malayi (Bm) sequences from previous work were also included [4].