Figure 5

Adaptive changes in metabolic and cellular processes in the small intestine during fasting. The significance of changes in mRNA levels within (a group of) pathways across time was analysed with MetaCore™ software. The P-values in the pathways are calculated using the hypergeometric distribution, where the P-value represents the probability of particular mapping arising by chance, given the numbers of genes in the set of all genes in pathways, genes in a particular pathway and genes in the present experiment. The pathways are grouped into processes as defined in MetaCore™ version 3.0. The dotted line represents the significance threshold (0.05). The daily percentual change of intestinal weight during fasting is shown on the secondary y-axis.