Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

BMC Genomics

Table 5 Promoter elements found to be enriched in the target promoter set relative to the background promoter set

Promoter elements	ORI	TAR (%)	BCG (%)	Probability of finding PE in target set	Probability of finding PE in background set	TAR (n)	BCG (n)	TAR Total	BCG Total	P-value
-1 MAZR	11.5685	5.7	2.07	0.00009	0.00002	31	212	544	10255	0.002
+1 MAZR	5.6322	5.15	2.08	0.00005	0.00002	28	213	544	10255	0.033
-1 TATA	2.9231	16.36	9.76	0.00017	0.00010	89	1001	544	10255	0.002
-1 TFII-I	2.8865	18.2	10	0.00017	0.00011	99	1025	544	10255	<0.001
-1 MAZ	2.6342	29.96	20.03	0.00040	0.00022	163	2054	544	10255	<0.001

The criteria for selecting PE as enriched was that it has to appear in at least 5% of the target promoter sequences and to have over-representation index (ORI) of at least 2. PE that appear in statistically significant proportion in the target set are denoted by + in the ORI column.

ISSN: 1471-2164