Figure 3

Genes involved in apoptotic pathways were altered in type II cells isolated from Stat3^Δ/Δ mice. Genes associated with apoptosis were identified via literature mining using Pathway Studio 4.0 (Ariadne Genomics, Inc.). STAT3 regulates apoptosis positively and negatively, via processes occurring in multiple intracellular compartments. Genes up-regulated in Stat3^Δ/Δ mice are framed in red. Genes down-regulated in Stat3^Δ/Δ mice are framed in green. Each dashed line demarcated with a larger dot linking "apoptosis" and each gene node indicates a regulatory relationship based on the literature references. Regulatory relationships are denoted by line colors (green, positive regulation; red, negative regulation; and gray, regulation direction is unknown).