Figure 4

Sequence conservation of different groups in mouse. The graphs show the conservation curve of mouse adjacent alternative exons around the donor and acceptor sites, based on the alignment between mouse and human (mouse-referenced, see methods). The x- and y-axis are the same as Figure 3. Results in the mouse are consistent with what was seen in the human: the strongly-correlated groups are more conserved than the weakly-correlated group, in both exon and flanking introns; the intermediate introns in the strongly-correlated groups are even more conserved. The conservation difference is also observed between the upstream and downstream exons. Compared with Figure 3, the difference between the upstream and downstream exons is less pronounces for the ME group, but it's more clear in the IND group.