| Â | Tissue M | Tissue N | Pooled |
|---|
exons | +D | -D | +D | -D | +D | -D |
|---|
+U | 9 | 81 | 9 | 1 | 18 | 82 |
-U | 1 | 9 | 81 | 9 | 82 | 18 |
- * +/- means the upstream (U) or downstream (D) exon in a pair is included/excluded in the transcript. In tissue M, the inclusion levels are 0.9 for U and 0.1 for D. In tissue N, the levels in 0.1 for U and 0.9 for D. The correlation coefficients between U and D are 0 in both M and N. But in pooled observation, the data show a strong negative correlation (-0.64). The cause of correlation in pooled data is not by the direct interaction between the two exons but the tissue-specific regulation.
