Figure 1

The content of IFN-αs after R11567DA administration. Four hours after oral administration of R11567DA at 100 mg/kg, the small and large intestines were removed, homogenized, and centrifuged. The amounts of IFN-αs were measured by ELISA as described in Materials and Methods. Data represent mean ± SEM (n = 3). LI, large intestine; SI, small intestine, N.D., not detected (under detection limit), *, p < 0.0001 vs SI. Without R11567DA treatment, IFN-αs were not detected in any tissues or sera. This experiment was repeated twice with similar results.