Table 1 Experimental design of the training and test samples
Compound | Time (hr) | Dose (mg/kg body weight) | Observed Hepatotoxicity | ||
|---|---|---|---|---|---|
Training | Â | Low | Mid | High | Â |
1,2-dichlorobenzene | 6/24/48 | 15 | 150 | 1500 | centrilobular necrosis |
1,4-dichlorobenzene | 6/24/48 | 15 | 150 | 1500 | centrilobular necrosis |
bromobenzene | 6/24/48 | 25 | 75 | 250 | centrilobular necrosis |
diquat | 6/24/48 | 5 | 10/20 | 25 | centrilobular, midzonal, focal necrosis |
galactosamine | 6/24/48 | 25 | 100 | 400 | multifocal necrosis |
monocrotaline | 6/24/48 | 10 | 50 | 300 | centrilobular, midzonal necrosis |
N-nitrosomorpholine | 6/24/48 | 10 | 50 | 300 | centrilobular necrosis |
thioacetamide | 6/24/48 | 15 | 50 | 150 | centrilobular necrosis |
Test | Â | Â | Â | Â | Â |
acetaminophen (NCT 008) | 6/24/48 | 50 | 150 | 1500/2000 | Â |
acetaminophen (NTP) | 6/18/24/48 | 50 | 150 | 1500/2000 | centrilobular necrosis |
acetaminophen (informatics challenge) | 3/6/12/24 | Â | 150 | 1500/2500 | Â |
carbon tetrachloride | 3/6/24/72 | 15 | 750 | 2000 | centrilobular necrosis |
Ally Alcohol | 6/24/48/72 | 10 | 20 | 40/50 | periportal necrosis |