Figure 1

Treatment with topoisomerase II inhibitors and potential topoisomerase II inhibitors: Frequency of the number of distances < 100 kbp between transcription start sites (TSSs). The number of distances < 100 kbp between TSSs was calculated for 100 randomized gene lists on the one hand and for the different significant gene lists stemming from human hepatocytes and mouse lymphoma cells treated with different topoisomerase II inhibitors and potential topoisomerase II inhibitors, respectively, on the other hand. The number of distances < 100 kbp between TSSs of the significantly regulated genes is marked by a black arrow in the corresponding histograms.