Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer

Table 6 Conservation of overlapping TFBS between human and other mammals^a

Gene	WT1/EGR1	SP1/EGR1	WT1/SP1	WT1/SP1/EGR1
ECAD	0	0	1233–1249: C	0
EGR1	608–630: Pr, Ro, Op	703–727: Pr	1340–1360: M	563–581: Pr
	1029–1047: C		1466–1486: M	1466–1490: M
GATA2	0	0	282–300: M	0
			892–910: Pr
			1125–1145: Pr
IGFBP2	0	1327–1359: Pr, Ro, Op	716–744: C	0
			1445–1463: C
KLK3	0	1400–1418: Pr	0	0
NDRG1	0	0	0	0
NPY	512–530: Pr	0	260–278: Pr	0
SOX4	0	1344–1362: C	0	0
SOX9	0	0	908–932: Pr	908–932: Pr
TFAP2C	0	1127–1145: Pr, Ro	0	0
		1160–1179: Pr
		1384–1403: Pr, Ro, Op
WT1	0	0	1089–1108: C	0
			1409–1434: C

^a Position numbers are based on predicted TFBS in the human sequences. Pr = Both primates (chimpanzee and macaque), C = chimpanzee, M = macaque, Ro = Both rodents (mouse and rat), Op = opossum. 0 = No overlapping WT1/EGR1, SP1/EGR1, WT1/SP1, or WT1/SP1/EGR1 TFBS for that particular gene.

ISSN: 1471-2164