Table 1 Genes responsive to PI3K, mTOR and p70S6K inhibitions in breast cancer cell lines.
From: Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
BT-474 breast cancer cell line, RPS6KB1-suppressed | |||
|---|---|---|---|
Gene Name | Description | Inhibitor | Expression |
ARL11 | ADP-ribosylation factor-like 11 | Ly294002 | U |
B2M | beta-2-microglobulin | Ly294002 | U |
CECR1 | cat eye syndrome chromosome region, candidate 1, transcript variant 1 | Ly294002 | U |
PCDH10 | protocadherin 10, transcript variant 1 | Ly294002 | U |
PCDH11Y | protocadherin 11 Y-linked, transcript variant c | Ly294002 | U |
PPP1R12B | protein phosphatase 1, regulatory (inhibitor) subunit 12B, transcript variant 3 | Ly294002 | U |
PSORS1C1 | psoriasis susceptibility 1 candidate 1 | Ly294002 | U |
ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | Ly294002 rapamycin | U |
CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), transcript variant 1 | rapamycin | U |
MCF-7 breast cancer cell line, RPS6KB1-suppressed | |||
Gene Name | Description | Inhibitor | Expression |
COL5A1 | collagen, type V, alpha 1 | Ly294002 | U |
FAM5C | family with sequence similarity 5, member C | Ly294002 | U |
RELB | v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) | Ly294002 | U |
SOX15 | SRY (sex determining region Y)-box 15 | Ly294002 | U |
ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | Ly294002 | U |
VTCN1 | V-set domain containing T cell activation inhibitor 1 | Ly294002 | D |
IFI44L | interferon-induced protein 44-like | rapamycin | D |
OASL | 2'-5'-oligoadenylate synthetase-like, transcript variant 1 | rapamycin | D |
SCD | stearoyl-CoA desaturase (delta-9-desaturase) | rapamycin | D |