Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate

BMC Genomics

Table 7 Differentially expressed genes encoding kinases in artesunate-treated cells

Gene ID	Description	Kinase type	Name	ART 90 min	ART 3 h	CQ
PFL0040c	protein kinase, R45/FIKK family	R45/FIKK	FIKK12	0,88	1,16
MAL7P1.144	protein kinase, R45/FIKK family	R45/FIKK	FIKK7.1	0,90	1,82
PFI0095c	protein kinase, R45/FIKK family	R45/FIKK	FIKK9.1	0,83	1,28
PF11_0510	protein kinase, R45/FIKK family	R45/FIKK	FIKK11		0,95
PFD1165w	protein kinase, R45/FIKK family	R45/FIKK	FIKK4.1		1,05
PFL1885c	calcium/calmodulin-dependent protein kinase 2, putative	kinase	PfPK2	1,35	1,21
PFL2280w	cyclin g-associated kinase, putative	kinase			1,10
PF14_0346	cGMP-dependent protein kinase 1, beta isozyme, putative	kinase			1,03
PF11_0242	protein kinase	kinase			0,95
PF14_0294	mitogen-activated protein kinase 1, PfMAP1	kinase	PfMAP1		1,05
PFD0975w	ROI kinase-like protein	RIO1			0,90	+
PF11_0377	casein kinase 1, PfCK1	kinase			-0,91	+
PF11_0227	serine/threonine protein kinase, puative	kinase			-0,98
PFB0150c	protein kinase, putative	kinase			-1,05

Gene ID: identifier as found in PlasmoDB.
Art columns: log ratios of gene expression under artesunate exposure at 90 minutes and 3 hours.
CQ column: over (+) or under (-) expression.
Results were compared with transcriptome modifications induced by heat-shock (HS) [12] and chloroquine (CQ) [8].
Kinases were defined as genes fitting the HMM profil kinase PF00069 (update of Ward et al. [39]) and ROI Kinases as genes fiiting the HMM profil PF01163. FIKK kinases were defined as described in Schneider and Puijalon [41].

ISSN: 1471-2164