Table 2 Validation by RNA interference data
From: Inferring gene regulatory networks by thermodynamic modeling
Role | TF | # of target genes | # of genes verified in RNAi | Chi-Square | P-value |
|---|---|---|---|---|---|
Activation | Nanog | 39 | 9 | 9.710604 | 0.00183 |
| Â | Sox2 | 121 | 20 | 16.22083 | 5.6E-05 |
| Â | Oct4 | 67 | 13 | 25.26604 | 5E-07 |
| Â | Esrrb | 95 | 6 | 2.966206 | 0.085021 |
| Â | Tcl1 | 21 | 2 | 4.650429 | 0.03105 |
| Â | Klf4 | 49 | 16 | 25.21262 | 5.1E-07 |
Repression | Nanog | 47 | 2 | 0.018713 | 0.891192 |
| Â | Sox2 | 132 | 12 | 9.035917 | 0.00265 |
| Â | Oct4 | 103 | 7 | 3.909397 | 0.04802 |
| Â | Esrrb | 73 | 6 | 5.407721 | 0.02005 |
| Â | Tcl1 | 27 | 2 | 4.663594 | 0.03081 |
| Â | Klf4 | 62 | 10 | 0.537394 | 0.463515 |