Table 5 The binding energy of peptide substrates in the models of the active site of cathepsins in T. molitor compared to that of human cathepsin L1 (3OF8), using the substrates FRF and LRF
Cathepsin | Free energy of binding (kcal/mol) | |
|---|---|---|
Substrate FRF | Substrate LRF | |
Human cathepsin L1 | −7.7 | - 6.1 |
TmL2 | −7.6 | - |
TmL5 | −7.1 | −3.3 |
TmL7 | - | - |
TmL8 | - | - |
TmL13 | −6.9 | −5.5 |
TmB18 | −7.6 | −3.9 |
TmB33 | −8.7 | −6.6 |