Figure 2

Phenotypic manifestation of the FH2-associated mutation(s). Photograph of a 15-months old Fleckvieh bull being homozygous for the rs379675307 mutation in SLC2A2 (A). Histological sections of the liver (B). Micrographs of PAS-stained liver specimens from the homozygous animal (upper panel) and from an unaffected control animal (lower panel). PAS-D shows the positive diastase test. Histological sections of the kidney (C). Micrograph of PAS stained kidney specimens from the homozygous animal (upper panel) and from an unaffected control animal (lower panel). PAS-D shows the positive diastase test. Two nineteen weeks old Fleckvieh calves (E). The calf on the left side is homozygous for the SLC2A2 mutation and the calf on the right side is a healthy animal. Photograph of a nine weeks old Fleckvieh calf homozygous for the SLC2A2-mutation (F). Please note the lean body of the FH2-homozygous calf. The affected animal (right side) is compared with a seven weeks (left side) old coeval (G). Figures were kindly supplied by Martina Wassertheurer (NOE Genetik, Austria). The weight of two FH2-homozygous twin calves (orange and red diamonds) is compared to the weight of 74,422 Fleckvieh calves with unknown genotypes (grey boxes) (D). The solid blue line represents the weaning period of the two homozygous calves.