NF-κB and IRF pathways: cross-regulation on target genes promoter level

BMC Genomics

Table 1 Summary of TFBS counts in dataset

Gene	Species	IRF family	of which IRF3	NF-κB family	of which REL
IRF1	Human (var*)	1	0	37	13
	Mouse (var)	0	0	23	8
	Chimpanzee	1	0	37	13
	Cattle	2	0	40	14
IRF2	Human	7	2	12	6
	Mouse (var)	8	2	24	8
	Chimpanzee	4	1	10	7
	Cattle	8	2	21	7
IRF3	Human (var)	1	1	5	4
	Mouse (var)	2	1	17	9
	Chimpanzee	2	1	5	4
	Cattle	2	1	12	5
NFKB1	Human	6	2	21	6
	Mouse (var)	1	0	3	2
	Chimpanzee	5	2	19	5
	Cattle	5	0	2	2
NFKB2	Human (var)	0	0	24	8
	Mouse (var)	0	0	24	8
	Chimpanzee	0	0	25	8
	Cattle	0	0	27	9
RELA	Human	1	0	18	6
	Mouse	2	1	14	6
	Chimpanzee	1	0	6	2
	Cattle	0	0	8	4
REL	Human	1	0	28	5
	Mouse	0	0	28	7
	Chimpanzee	1	0	21	3
	Cattle	7	0	4	1

Summary of the counts of TFBS corresponding to the members of IRF and NF-κB families of transcription factors found in the promoters of presented genes in four species: human, mouse chimpanzee and cattle. Motifs overlap; numbers in bold correspond to promoters containing 2 or more IRF3 motifs. Detailed results are presented in Additional file 1. *var – other variants of the promoter exist.

ISSN: 1471-2164