Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

Goossens-Beumer, Inès J; Oosting, Jan; Corver, Wim E; Janssen, Marjolein JFW; Janssen, Bart; van Workum, Wilbert; Zeestraten, Eliane CM; van de Velde, Cornelis JH; Morreau, Hans; Kuppen, Peter JK; van Wezel, Tom

doi:10.1186/s12864-015-1550-0

BMC Genomics

Table 2 Colorectal cancer studies reporting on copy number alterations

From: Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

	Studies		Origin of tissues	Method	Total CRC		Rectum		Colon		TNM stage
					Figure 1 A	#	Figure 1 B	#	Figure 1 C	#	TNM stage
1	Schlegel et al.	1995	Germany	CGH	yes	12	no	(x)	yes	12
2	Ried et al.	1996	Germany	CGH	yes	16	yes	6	yes	10	2/3/(4)
3	Meijer et al.	1998	the Netherlands	CGH	yes	14	yes	7	yes	7
4	Nakao et al.	1998	Japan	CGH	yes	9	no	0	yes	9	(1)/3
5	Paredes-Zaglul et al.	1998	USA	CGH	yes	9	yes	2	yes	7	(3)/4
6	Al-Mulla et al.	1999	UK	CGH	yes	12	no	(x)	no	(x)	2/3
7	De Angelis et al.	1999	Norway	CGH	yes	45	no	(x)	no	(x)	2/3/4
8	Georgiades et al.	1999	UK	CGH	yes	17	no	(11)	no	(6)	1/2/3
9	Korn et al.	1999	USA	CGH	yes	6	no	(0)	yes	6	2/3/4
10	Aust et al.	2000	USA/Germany	CGH	yes	42	no	(7)	no	(35)	1/2/3/4
11	Aragane et al.	2001	Japan	CGH	yes	30	no	(x)	no	(x)	1/2/3/4
12	Chan et al.	2001	China/UK	CGH	yes	16	no	(x)	no	(x)	2/3/4
13	De Angelis et al.	2001	Norway	CGH	yes	67	no	(x)	no	(x)	1/2/3/4
14	Nakao et al.	2001	Japan	CGH	yes	35	no	(13)	no	(22)	2/3/4
15	Rooney et al.	2001	USA	CGH	yes	29	no	(4)	no	(25)	3
16	Hermsen et al.	2002	the Netherlands	CGH	yes	82	no	(x)	no	(x)	1/(2)
17	Knösel et al.	2002	Germany	CGH	yes	15	no	(x)	no	(x)
18	Alcock et al.	2003	UK	CGH	yes	17	yes	6	yes	11
19	Ghadimi et al.	2003	Germany	CGH	yes	50	yes	18	yes	32	1/2/3
20	He et al.	2003	China	CGH	yes	26	yes	14	yes	12	2/3/4
21	Leslie et al.	2003	UK	CGH	yes	50	no	(21)	no	(29)	1/2/3
22	Bardi et al.	2004	Sweden/Denmark	CGH	yes	115	no	(51)	no	(63)	1/2/3/4
23	Diep et al.	2004	Norway/Sweden	CGH	yes	10	no	(x)	no	(x)	(3)/4
24	Nakao et al.	2004	Spain	aCGH	yes	125	no	(x)	no	(x)	1/2/3/4
25	Poeaim et al.	2005	Thailand	CGH	yes	40	no	(10)	no	(30)
26	Tanami et al.	2005	Japan	CGH	yes	20	yes	9	yes	11	(2)/(3)/4
27	Al-Mulla et al.	2006	UK/Kuwait	CGH	yes	70	no	(47)	no	(18)	1/2
28	Grade et al.	2006	Germany	CGH	yes	21	yes	21	no	0	2/3
29	Grade et al. ^a	2007	Germany	CGH	yes	32	no	0	yes	32	2/3
30	Lips et al.	2007	the Netherlands	SNPa	yes	77	yes	77	no	0	1/2/3
31	Xiao et al.	2007	China	CGH	yes	24	yes	9	yes	15
32	Lips et al.	2008	the Netherlands	SNPa	yes	32	yes	32	no	0	1/2/(3)
33	Grade et al. ^a	2009	Germany	CGH	yes	42	yes	42	no	0	1/2/3
34	Lagerstedt et al.	2010	Sweden	aCGH	yes	24	no	(x)	no	(x)	1/2/3/4
35	Molinari et al.	2011	Italy	aCGH	yes	51	yes	51	no	0	1/2/3
36	Nakao et al.	2011	Japan	aCGH	yes	94	no	(x)	no	(x)	1/2/3/4
37	Chen et al. ^b	2011/2012	USA	aCGH	yes	95	yes	95	no	0	2/3
38	Kodeda et al.	2012	Sweden	aCGH	yes	16	yes	16	no	0	1/2/3
39	Shi et al.	2012	China	aCGH	yes	8	yes	8	no	0
40	Liang et al.	2013	China	aCGH	yes	48	yes	48	no	0	2/3/4
41	Zhou et al.	2013	China	aCGH	yes	16	yes	16	no	0	2/3
42	Doyen et al.	2014	France/Germany	SNPa	yes	80	yes	80	no	0	(1/2/3)
43	This study	2014	the Netherlands	SNPa	yes	112	yes	112	no	0	1/2/3
	Total				43		20		12

This table lists the published studies on CN alterations in rectal carcinomas used for comparisons with the present study (Nr. 43).
Abbreviations: CGH, comparative genome hybridization; aCGH, arrayCGH; SNPa, SNP array; ^aUnclear if there is overlap with study Nr. 29 (Grade et al. [29]), ^bChen et al. published two papers based on the same patient cohort. Numbers in parentheses indicate the number of rectal or colon cancer patients included in the study, but for which results could not be distinguished between groups.

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