Fig. 2

Analysis of p53 REs found in human promoters. a Pie chart displaying the distribution of grades associated to REs found in all human promoters. b Comparison between the frequencies of REs found in human promoters, and the frequencies of REs found in scrambled promoter sequences after applying local permutations (to preserve the local GC content). The comparison is shown for each grade. The ratio is 1 if the frequency is the same, > 1 if the frequency is higher in real promoters, <1 if the frequency is higher in scrambled promoters. All enrichments are significant, the binomial test p-value is 4.84E-04 for grade 5 (**), <1E-15 for all the other grades (***). c p53 occupancy metaprofile, based on the position of REs in all human promoters, centered on the TSS position. The grey histogram displays the probability distribution of all REs independently from the grade. Colored lines represent the density distribution of REs with higher grades (the grade threshold corresponding to each color is displayed in the legend). The specific positions of grade 5 REs are dotted in yellow under the histogram. d p53 occupancy metaprofile, based on the position of REs in the human promoters of 228 p53 target genes, published in [15]. The color scheme is the same as in panel C. The specific positions of grade 4 and 5 REs are dotted under the histogram (in yellow for grade 5, red for grade 4)