Fig. 1

Significantly more promoters with orphan and unstable repeats in tumors. Box plots of the number of gene promoters a) with orphan repeats b) with unstable repeats in normal-normal genome pairs (left boxes, n = 595) and in tumor-matched normal genome pairs (right boxes, n = 35) in promoter sequences. Thick horizontal lines in each box mark the median, edges of boxes correspond to the 25th and 75th percentiles, and whiskers cover 99.3 % of the data’s range. The repeat incidences in each pair of boxes are significantly different from each other within each panel (WRS Test, P < 10⁻¹⁶, P < 10⁻²⁴, in panels a and b)