Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis

Table 3 Frequent chromosome losses and gains involving single genes

Number of samples	Type	Chromo some	Band	Gene	miRNA	GV
7	Gain	7	p11.2	EGFR		-
7	Gain	1	p36.32	PRDM16	hsa-mir-551ahsa-mir-551a	v
7	Loss	12	q24.13	PTPN11		-
7	Gain	2	q31.1	HOXD11, HOXD13 HOHOHOXD13 HOXD11HOXD13		v
6	Loss	13	q12.2	FLT3		-
6	Gain	9	q22.32	PTCH		v
5	Loss	8	p11.22	FGFR1		-
5	Loss	3	p13	FOXP1		-
5	Gain	X	q26.2	GPC3		-
5	Gain	12	q13.13	HOXC13, HOXC11	hsa-mir-196a-2	v
5	Loss	22	q13.1	MKL1		v
5	Loss	22	q12.1	CHEK2		v

The column “Number of samples” represents the number of patients with a particular genomic abnormality. For each variation the type of variation (gain or loss), location on chromosome and band, the gene located in this locus and miRNAs located in this locus are enlisted. Variants reported in the Database of Genomic Variants (DGV) database in genes are denoted as “v” and if none reported as “-” under the column DGV

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