MiR-210 promotes sensory hair cell formation in the organ of corti

Riccardi, Sabrina; Bergling, Sebastian; Sigoillot, Frederic; Beibel, Martin; Werner, Annick; Leighton-Davies, Juliet; Knehr, Judith; Bouwmeester, Tewis; Parker, Christian N.; Roma, Guglielmo; Kinzel, Bernd

doi:10.1186/s12864-016-2620-7

BMC Genomics

Table 2 Putative miR-210 targets identified by integrative analysis

From: MiR-210 promotes sensory hair cell formation in the organ of corti

Class	Gene ID (mouse)	Gene symbol (mouse)	Reported in the literature as (MetaBase)	Computationally inferred for (TargetScan)	Not in Wang et al. or He et al.	In Wang et al. (2014)	In He et al. (2012)
1	72168	Aifm3	Present	Mouse and Human	TRUE	FALSE	FALSE
1	12043	Bcl2	Present	Mouse and Human	FALSE	TRUE	FALSE
1	18033	Nfkb1	Present	Mouse and Human	TRUE	FALSE	FALSE
1	12176	Bnip3	Present	Mouse and Human	TRUE	FALSE	FALSE
1	20423	Shh	Present	Mouse and Human	TRUE	FALSE	FALSE
1	20852	Stat6	Present	Mouse and Human	TRUE	FALSE	FALSE
1	21416	Tcf7l2	Present	Mouse and Human	TRUE	FALSE	FALSE
2	56336	B4galt5	Probably present	Mouse and Human	FALSE	TRUE	FALSE
2	66383	Iscu	Probably present	Mouse and Human	FALSE	TRUE	FALSE
2	12064	Bdnf	Probably present	Mouse and Human	FALSE	TRUE	FALSE
2	53417	Hif3a	Probably present	Mouse and Human	FALSE	TRUE	FALSE
2	13638	Efna3	Probably present	Mouse and Human	TRUE	FALSE	FALSE
2	17992	Ndufa4	Probably present	Mouse and Human	FALSE	TRUE	FALSE
3	333433	Gpd1l	Not likely present	Mouse and Human	FALSE	TRUE	TRUE
3	381022	Kmt2d	Not likely present	Mouse and Human	FALSE	TRUE	FALSE
3	22661	Zfp148	Not likely present	Mouse and Human	TRUE	FALSE	FALSE
3	68041	Mid1ip1	Not likely present	Mouse and Human	FALSE	TRUE	FALSE
3	231207	Cpeb2	Not likely present	Mouse and Human	TRUE	FALSE	FALSE
3	170729	Scrt1	Not likely present	Mouse and Human	TRUE	FALSE	FALSE
3	240057	Syngap1	Not likely present	Mouse and Human	FALSE	FALSE	TRUE
3	74287	Kcmf1	Not likely present	Mouse and Human	FALSE	TRUE	FALSE
3	18013	Neurod2	Not likely present	Mouse and Human	TRUE	FALSE	FALSE
4	207393	Elfn2	Absent	Mouse and Human	FALSE	TRUE	FALSE
4	17258	Mef2a	Absent	Mouse and Human	TRUE	FALSE	FALSE
4	74244	Atg7	Absent	Mouse and Human	FALSE	TRUE	FALSE
5	69662	2310061I04Rik	Absent	Mouse or Human	FALSE	TRUE	FALSE
5	225791	Zadh2	Absent	Mouse or Human	FALSE	TRUE	FALSE
5	52132	Ccdc97	Absent	Mouse or Human	FALSE	TRUE	FALSE
5	210573	Tmem151b	Absent	Mouse or Human	TRUE	FALSE	FALSE
5	20362	Sept8	Absent	Mouse or Human	TRUE	FALSE	FALSE
5	433940	Fam222a	Absent	Mouse or Human	TRUE	FALSE	FALSE
5	320717	Pptc7	Absent	Mouse or Human	FALSE	TRUE	FALSE
5	545554	Ankrd34a	Absent	Mouse or Human	TRUE	FALSE	FALSE
5	11515	Adcy9	Absent	Mouse or Human	TRUE	FALSE	FALSE
5	102247	Agpat6	Absent	Mouse or Human	TRUE	FALSE	FALSE

Genes are displayed in five different classes based on the nature of the supporting evidence (literature-verified versus computational prediction). Literature-verified miRNA/mRNA interactions retrieved from MetaBase were annotated according to the ‘trust’ of the source into “Present”, “Probably present”, “Not likely present”, or “Absent” (e.g. if not available). Computational inferred interactions identified by TargetScan were classified in two different groups, based on whether targets were predicted for the two species analyzed (“Mouse and Human”) or only one (“Mouse or Human”). Predicted targets were compared to previous reports and identical findings annotated as “true” or “false”

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ISSN: 1471-2164

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