From: Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure
N.° | Pre-conditioning agent | Biocide Phenotype | Biocide MIC (mg/L) | Antibiotic MIC (mg/L) | Mutant designation | Fitness Cost (%) | Frequency of mutation | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TRI | BKC | CHX | AMP | CAZ | CIP | ERY | GEN | CLO | TET | ||||||
- | Parental strain SL1344 | 0.06 | 16 | 16 | 1.5 | 0.38 | 0.032 | 32 | 1.0 | 3 | 3 | ||||
1 | NE | TRIR/BKCR/CHXR | 2 | 32 | 32 | 1.5 | 0.38 | 0.047 | 32-48 | 1.5 | 3 | 2 | NE/TRI1 | 11 | >1.25E-07 |
2 | NE | 0.12 | 32 | 32 | 1 | 0.25 | 0.032 | 32 | 1.0 | 4 | 4 | NE/CHX2 | 34 | 2.92E-09 | |
3 | BKC | 0.12 | 32 | 32 | 2 | 0.38 | 0.023 | 32 | 1.5 | 3 | 4 | BKC/AMP | - | 2.50E-09 | |
4 | CHX | 0.12 | 32 | 32 | 1 | 0.5 | 0.032 | 48 | 1.5 | 2 | 2 | CHX/BKC3 | - | 1.67E-09 | |
5 | BKC | TRIR/BKCR | 0.12 | 32 | 16 | 2 | 0.38 | 0.032 | 48 | 0.5 | 4 | 4 | BKC/BKC3 | - | 2.50E-09 |
6 | CIP | BKCR | 0.06 | 32 | 16 | 1.5 | 0.5 | 0.032 | 24 | 1.5 | 2-3 | 1.5 | CIP/TRI1 | More fit | <1.50E-05 |
7 | TRI | 0.06 | 32 | 16 | 2 | 0.5 | 0.032 | 32 | 1.5 | 3 | 2-3 | TRI/BKC3 | 31 | 1.50E-09 | |
8 | NE | BKCR/CHXR/TRIHS | 0.03 | 32 | 32 | 2 | 0.38 | 0.032 | 32-48 | 1 | 4 | 4 | NE/BKC2 | - | 1.25E-07 |
9 | NE | 0.03 | 32 | 32 | 1.5 | 0.75 | 0.047 | 24 | 1.5 | 3 | 1.5 | NE/BKC3 | more fit | 2.08E-11 | |
10 | TRI | 0.015 | 32 | 32 | 1.5 | 0.5 | 0.032 | 24 | 1.5 | 2 | 1.5 | TRI/AMP | - | 3.06E-09 | |
11 | BKC | 0.015 | 64 | 32 | 2 | 0.38 | 0.023 | 32 | 1 | 3 | 4 | BKC/CHX2 | - | 1.67E-08 | |
12 | CIP | TRIHS/CHXHS | 0.03 | 16 | 8 | 2 | 0.38 | 0.032 | 32 | 2 | 4 | 3 | CIP/CHX1 | - | <2.50E-06 |
13 | BKC | TRIHS | 0.015 | 16 | 16 | 1 | 0.38 | 0.023 | 64 | 1.5 | 3 | 1.5 | BKC/CIP | - | 1.50E-09 |
14 | CHX | 0.015 | 16 | 16 | 2 | 0.38 | 0.023 | 32-48 | 0.75 | 3 | 4 | CHX/AMP | 17 | 4.17E-09 |