Fig. 3
From: Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin
Sequence variances in disordered tails. Information on the mutation and modification of beta-Catenin was extracted from UniProtKB, COSMIC, BioMute, and DMBM. a Occurrences of five different types of mutations. The types of mutations from top to bottom are: (1) missense mutation, (2) synonymous mutation, (3) in-frame deletion, (4) frameshift deletion, and (5) insertion. X-axis shows the amino acid sequence. Y-axis is the occurrences of mutations. The plots in (1), (2), and (5) show the number of point mutations at each site. The lines in (3) and (4) represent deleted segments. b Mutations and post-translational modifications in the N-terminal tail of beta-Catenin. The upper inset shows a non-redundant set of functional motifs at the N-terminal tail of beta-Catenin. The middle inset demonstrates mutations from UniProtKB for the N-terminal tail and Tyr-654 near the C-terminal tail. Red bars stand for natural variants and pink bars for mutagenesis sites. The character label “wt” and the numbers at the left-hand side indicate wild type (wt) and mutations (1, 2, and 3). Lower inset shows observed post-translational modifications in both N- and C-terminal tails