Table 3 Prioritized core vaccine candidates against Acinetobacter baumannii
Protein name | T Cell Epitope | Location (aa) | Total number of MHC binding alleles | VaxiJen Score (Antigenicity) (Cut-off value 0.4) | Virulence score (Threshold 0.5) | COG | KEGG Description |
|---|---|---|---|---|---|---|---|
P pilus assembly protein (HMPREF0010-00599) | WGDESNERC | 820-829 | 18 | 1.85 | 1.0600 | COG3188 | P pilus assembly protein, porin PapC |
adeK | YNSASGTSI | 44-52 | 30 | 1.9336 | 1.0621 | COG1538 | Multidrug resistance outer membrane protein |
ompA | YNVDASRLS | 298-306 | 12 | 1.6125 | 1.0578 | COG2885 | ompF-ompA porin family |
General secretion pathway protein D (HMPREF0010_01958) | YQQVPSGGK | 706-714 | 7 | 0.6490 | 1.0605 | COG1450 | Bacterial secretion system |
FhuE receptor (HMPREF0010-00709) | IKLYDSNVN | 641-649 | 19 | 1.3939 | 1.0598 | COG4773 | Inorganic ion transport and metabolism |
General Secretion pathway protein D (HMPREF0010_02518) | IQSSGSYEY | 221-229 | 12 | 1.1190 | 1.0606 | COG4796 | Type II secretory pathway |
Type VI secretion system OmpA/MotB (HMPREF0010_01378) | LYLDQKEKK | 75-83 | 9 | 0.881 | 1.0607 | COG2885 | ompF-ompA porin family |
Ton B dependent siderophore receptor (HMPREF0010_01517) | YSGDSQLNA | 286-294 | 5 | 1.4266 | 1.0636 | COG4771 | Iron complex Outer membrane receptor |
Outer membrane protein (29_170) | IAGNQNLKA | 82-90 | 9 | 1.8656 | 1.0596 | COG1538 | Outer membrane protein |
Peptidyl-prolyl cis-trans isomerase (HMPREF0010_03292) | LQTMKEGGK | 185-193 | 4 | 0.98 | 1.0610 | COG0545 | FKBP-type peptidyl-prolyl cis-trans isomerase |
Peptidoglycan-associated lipoprotein (HMPREF0010_02142) | YQTLQAHAQ | 91-99 | 17 | 0.72 | 1.0606 | COG2885 | ompF-ompA porin family |
Pilus assembly chaperone (HMPREF0010_002598) | IKEDANLAA | 159-167 | 20 | 0.9917 | 1.0607 | COG3121 | Pilus assembly protein |
ponA/Penicillin binding protein 1a | FLIIIIILV | 15-23 | 54 | 2.1254 | 1.0606 | COG5009 | Cell wall/membrane biogenesis |